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Полимерные имплантаты для замещения дефектов костной и хрящевой ткани
Polymer composite material for the production of joint endoprostheses is developed: 1) Developed an experimental technology for material for manufacturing endoprostheses 2) A complex of structural, tribological and mechanical tests was done 3) Biomedical tests in vitro and in vivo were done The problems to increase the mechanical properties of the implant material, improve the wear resistance of the polymer implant, reduce the coefficient of friction, while maintaining a high biocompatibility of the material were solved with reducing the number of fusion defects. Young's Modulus 1.5 GPa. High impact strength is achieved. The technology doesn't demand creation of the inert atmosphere that significantly reduces cost of production. Two-level composite material based on UHMWPE for bone implants is developed: 1) The experimental technology for obtaining the material and manufacturing implants is developed 2) A complex of structural, tribological and mechanical tests was done 3) Preclinical biomedical tests in vitro and in vivo were done. The technology of producing UHMWPE-composite materials with wide range of quantity and size of pores is developed. Laboratory samples of a two-layer implants were obtained. The first layer is a porous UHMWPE. The second layer is made of UHMWPE/HAP with a continuous structure to provide the necessary strength of implant. A bioresorbable polymeric material for bone implants is developed: 1) The experimental technology for obtaining the material and manufacturing implants is developed 2) A complex of structural, tribological and mechanical tests was done 3) Preclinical biomedical tests in vitro and in vivo were done The problem to maintain performance of implants during their resorption in the body, while ensuring the regeneration of bone tissue, was solved. High porosity and specific pore size allows cells to penetrate into the implant and remain on the surface. Over time there is resorption of the material and replacing it with bone. In this case, an implantable composite originally played the role of supporting and guiding element that promotes the growth of bone tissue, and later gradually resolves. The material provides the conditions for the adhesion and colonization of the surface by mesenchymal cells. In this case, the developed technology of manufacturing of materials and implants allows to obtain almost any shape of material without significant shrinkage.


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Doctor of Science, professor
Ph.D., associated professor
Ph.D., engineer
Ph.D., engineer


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Яндекс.Метрика