The University: Lomonosov Moscow State University, Chemistry Department
Country:Russia
City: Moscow
Department: Chemistry Department
Academic Position:
Associate professor, Deputy Dean
Academic Degrees and Titles:
Dr., PhD in chemistry, Doctor of sciences
Winner of open international NUST «MISiS» grant competition to support scientific research in a new scientific area, implemented under the supervision of leading scientists, and to establish a new laboratory
Area of Expertise:
Nanomaterials, functional materials, nanoparticles, bioinorganic chemistry, bioorganic chemistry, organic synthesis, nanochemistry
MajorScientificAdvances:
The scientific activity of the project leader Dr. Majouga is focused in the field of organic and inorganic materials synthesis for medical purposes.
Dr. Majouga found some new synthetic approaches that leads to biologically active compounds, including derivatives of heterocycles, peptides, transition metal coordination compounds.
Important role in the search for biologically active compounds plays nanohybrid materials. In his laboratory at MSU has developed a methodology of complex research of nanomaterials based on sulfur-containing ligands and metal nanoparticles.
Such materials have been successfully used in chromatography (for the separation of chiral drug enantiomers), catalysis (development of catalytic systems for exhaust gas afterburning), sensors (sensors getting heavy metal ions) .
Recent studies was devoted to the search for new anticancer drugs . Small molecule inhibitors have been found for the enzyme telomerase, described analogues of these drugs are highly effective in vitro and in vivo. Dr. Majouga heads the synthetic group (biologically active substances and materials) within the center of the MSU - SkTeh -MIT. As part of these studies will be new drugs for the treatment of liver cancer and prostate cancer.
Research of the Dr. Majouga's lab are international, between his laboratory and the University of Nottingham (UK) , the center of Nanomedicine and Drug Delivery University of Nebraska Medical Center (USA), pharmaceutical faculty of the University of North Carolina (USA) close cooperation was established.
Together with Professor Kabanov AV (USA), they found a new effect of low frequency magnetic fields on the biomolecules attached to the surface_ of the nanoparticles. This discovery, in the future, no doubt allow to construct a device for biomedical applications .
On the basis of these works , he has published more than 100 scientific papers in top-rated journals, including Angewandte Chemi, Coordinational Chemical Reviews, Polyhedron, Tetrahedron , etc.
Alexander Majouga is the author of more than 5 patents , including international . He takes part in the organization of specialized conferences and seminars, make oral presentations as a guest speaker at international events .
His staff and graduate students actively participate and win prizes in competitions research. Under his supervision about thirty graduate diploma works was done and he was the supervised of five PhD works.
Dr. Majouga actively implementing the results of scientific activities in the educational process . He create courses: "Chemistry of nanomaterials for biomedical applications", "Bioorganic Chemistry" for students enrolled in the specialization "Chemistry of living systems".
Dr. Majouga spend a lot of time for commercialization of innovations. He was the supervisor and organizer of several companies operating in the field of innovative entrepreneurship.
Awards:
Dr. Majouga A. was the winner of the Lomonosov Moscow state university (MSU) contest for young scientists ( 2006, 2007, 2009), he has awarded medal for young scientists of the RAS ( 2006 ) for the best work in the field of chemistry. He has been granted for the best innovative project of the Faculty of Chemistry (2008, 2009) and Lomonosov Moscow State University ( 2011 ). For his work in the field of education in 2010, he was awarded the title of "Excellent Education" from the Ministry of Education. Dr. Majouga AG member of the personnel reserve of the MSU. Member of the Council of Young Scientists of the Faculty of Chemistry , organizer and secretary of the seminar "Advanced Nanomaterials", member of educational-methodical commission "nanobiomaterials", organizer of the consortium "Chemistry of Functional Nanomaterials". Winner of the contest "Innovative technologies for the real economy and social sphere" (2009), winner of the contest " High technology - basis for the modernization and development of the industry ". Dr. Majouga is a member of the American Chemical Society , the International Society of bioinorganic Chemistry and Russian Mendeleev's society.
1. «Scientiavinces. Knowledge win. From the first president of Nikolaev " The Ministry of Education 2013 For system development work in chemical education, the formation of technical thinking in students republic
2. Excellence in Education The Ministry of Education 2009 Systematic work aimed at training talented pupils and students
3. Medal of the International forum "High Technologies of XXI Century" Government of Moscow 2009 For his work "The chromatographic system based on new nanohybrid materials for separation of active pharmaceuticals"
4. Medal of the International form of "High Technologies of XXI century» Government of Moscow 2009 For his work "Development of a method of analysis and purification of drugs"
5. Medal of the Russian Academy of Sciences Russian Academy of Sciences 2006 For his work "Universal oxidation catalysts"
Research Projectsand Contracts:
1. Chemical design of bionanomaterials for medical purposes Ministry of Education and Science of the Russian Federation 2010-2013
2. Center for RNA technology Skolkovo Technological University 2013-2017
3. Synthesis and preclinical testing of a new type of anticancer drug - telomerase inhibitor. Foundation for Assistance to Small Innovative Enterprises in Science and Technology 2012-2013
4.New ways of cancer therapy models G4-quadruplexes, the use of metal nanoparticles for targeted delivery and diagnostics. Russian Foundation monumental research 2012-2014
5. The use of nanoparticles for targeted delivery and stabilization of nucleic acids Ministry of Education and Science of the Russian Federation 2010-2012
6. New nanohybrid materials based on metal nanoparticles Ministry of Education and Science of the Russian Federation 2010-2012
7. New approaches to the creation of small molecule inhibitors of telomerase Russian Foundation monumental research 2012-2014
Referee, Reviewer:
Journal of nanoparticle research (2010 till now), Biochemie (2011 till now)
Scientific Recognition:
1. Expert at Skolkovo Fund (Biomed and nuclear clusters)
2. Expert at Analytical Center under the Government of the Russian Federation
3. Scientific advisor of the Center of national intellectual reserve
4. Member of the American Chemical Society
5. Member of the International Society of bioinorganic
6. Expert Education Accreditation Centre AKKORK
Patents, Intellectual Property:
1. Mazhuga AG Zverev ME, telomerase inhibitors and their method of preparation, Department of Chemistry, Lomonosov Moscow State University patent 09 April 2010 Россия, 09 April 2010 RU2010113946 09.05.2010
2. A.G.Mazhuga, M.I.Zvereva, TELOMERASE INHIBITORS AND A METHOD FOR THE PREPARATION THEREOF patent 05 April 2011 Европа, 05 апреля 2011 PCT/RU2011/000223 05 April 2011
3. Mazhuga AG, Ananeva IA Shpigun OA, EN Shapovalov, Beloglazkina EK, Zik NV, NS Zefirov A method for producing separation functional materials nanohybrid-modified nanoparticles of metals and their use in chromatography. Patent number 2366502 on September 10, 2009 patent 29 October 2009 Россия, 29 October 2027 №2366502 10 September 2009
4. Antibacterial drug and its production method. Mazhuga AG, Krutyakov YA, Kudrinskiy AA, GV Lisichkin Patent number 24194319 on October 29, 2009 patent 29 October 2009 Россия, 29 October 2009 г. № 24194319 29 October 2009
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1 Angew. Chem. Int. Ed. Klyachko N. L., Sokolsky-Papkov M., Pothayee N., Efremova M. V., Gulin D. A., Kuznetsov A. A., Majouga A. G., Riffle J. S., Golovin Y. I., Kabanov A. V. Change of the Enzyme Reaction Rate in Magnetic Nanosuspensions by Non-Heating Magnetic Field 2012, v. 51, N 48, p. 12016-12019 13,734
2 Dalton Transactions Majouga Alexander G., Beloglazkina Elena K., Moiseeva Anna A., Shilova Olga V., Manzheliy Eugeniy A., Lebedeva Maria A., Davies E.Stephen, Khlobystov Andrei N., Zyk Nikolay V. Cleavage of the C-S bond with the formation of a binuclear copper complex with 2-thiolato-3-phenyl-5-(pyridine-2-ylmethylene)-3,5-dihydro-4H-imidazole-4-on. A new mimic of the active site of N2O reductase 2013, 42, 18, 6290-6293 4,081
3 Studies in Surface_ Science and Catalysis Elena V. Golubina, Daria A. Pichugina, Alexander G. Majouga, Sultan A. Aytekenov Role of deposition technique and support nature on the catalytic activity of supported gold clusters: experimental and theoretical study 2010, v. 175, p. 297-300. 3,702
4 Успехи химии Е.К. Белоглазкина, А.Г. Мажуга, Р.Б. Ромашкина, Н.В. Зык, Н.С. Зефиров Наночастицы золота, модифицированные координационными соединениями металлов: синтез и применение 81, 65 2012 2,813
5 Tetrahedron Letters Alexander G. Majouga, Anna V. Udina, Elena K. Beloglazkina, Dmitrii A. Skvortsov, Maria I. Zvereva, Olga A. Dontsova, Nikolay V. Zyk, Nikolay S. Zefirov Novel DNA fluorescence probes based on 2-thioxo-tetrahydro-4H-imidazol-4-ones: synthetic and biological studies Volume 53, Issue 1, 4 January 2012, Pages 51-53 2,397
6 Diamond and Related Materials Golubina, E.V., Lokteva, E.S., Majouga, A.G., Lobanov, M.V., Lunin, V.V. Ultradispersed diamond as an excellent support for Pd and Au nanoparticle based catalysts for hydrodechlorination and CO oxidation Vol. 20, Issue 7, 2011, 960-964 1,822
7 Polyhedron Beloglazkina Elena K., Majouga Alexander G., Antipin Roman L., Myannik Kseniya A., Moiseeva Anna A., Zyk Nikolai V. Novel copper(II) and cobalt(II) complexes with selenium substituted imidazolyl imines. The molecular and crystal structure of [N-(2-(phenylseleno)ethyl)-N-(imidazol-2-ylmethylene)amine]copper(II) dichloride 2013, том 50, № 13, с. 425-433 1.813
8 Polyhedron Beloglazkina Elena K., Majouga Alexander G., Mironov Andrei V., Yudina Anna V., Moiseeva Anna A., Lebedeva Maria A., Khlobystov Andrei N., Zyk Nikolai V. Synthesis, X-ray crystallography and electrochemistry of three novel copper complexes with imidazole-containing hydantoin and thiohydantoins 2013, том 63, с. 15-20 1,813
9 Phosphorus, Sulfur, Silicon Elena K. Beloglazkina, Alexander G. Majouga, Anna A. Moiseeva, Nikolai V. Zyk Coordination compounds of S- and Se-containing organic ligands as catalysts of oxidation reaction under N2O action Volume 188, Issue 4, 2013 0,716
10 Mendeleev. Commun. Renata B.Romashkina, Elena K. Beloglazkina, Andrei N. Khlobystov Alexander G. Majouga, Daria A. Pichugina, Vladimir I. Terenin, Nikolai V. Zyk, and Nikolai S. Zefirov Copper (II) coordination compounds as building blocks for the formation of gold nanoparticle dimers 2011, 21, 129-131 1,052
11 Mendeleev Communications Petr V. Gorelkin, Dimitry S. Mukhin, Alexander G. Majouga, Renata B. Romashkina, Elena K. Beloglazkina, Igor V. Yaminsky and Nikolai V. Zyk. New self-assembled monolayer coated cantilever for histidine-tag protein immobilization. 2010, V. 20, № 6, с. 329-331 1.052
12 Mendeleev Commun P.G. Rudakovskaya, E.K. Beloglazkina, A.G. Majouga, N.V. Zyk. Synthesis and characterization of terpyridine-type ligands protected gold-coated Fe3O4 nanoparticles. 2010, № 3, с. 158-160 1,052
13 Mendeleev. Commun. Alexander G. Majouga, Elena K. Beloglazkina, Anna A. Moiseeva, Nikolai V. Zyk, Nikolai S. Zefirov Oxidation of triphenylphosphine and norbornene by nitrous oxidein the presence of CoIILCl2 [L=3-phenyl-5-(2-pyridylmethylene)-2-thiohydantoin]:the first example of CoII-catalyzed alkene oxidation by N2O 2009, 19, 69-71 1,052
14 Mendeleev. Commun. Alexander G. Majouga, Elena K. Beloglazkina, Anna A. Moiseeva, Nikolai V. Zyk, Nikolai S. Zefirov First example of the ring-opening transformation of thiazolidines to iminothiols on gold surface_ 2009, 19, 92-93 1,052
15 Российские нанотехнологии Елфимова Я. А., Пичугина Д. А., Ананьева И. А., Мажуга А. Г., Шпигун О. А. Закономерности удерживания аминопиридинов на силикагеле, модифицированном наночастицами золота 2012, 7, 3-4, 76-77 0,954
16 Российские Нанотехнологии P.Б. Ромашкина, Е.К. Белоглазкина, А.Г. Мажуга, Н.В. Зык. Получение наночастиц золота, модифицированных бис[13-(пиридин-4-ил)тридецил]дисульфидом и изучение их взаимодействия с ионами Cu(II) и Cu(I). 2009, 4, 9-10, 52-55. 0,954
17 ХГС А.Г. Мажуга, Р.Б. Ромашкина, А.С. Кашаев, Е. К. Белоглазкина, Р.Д. Рахимов, Н.В. Зык. Новые органические лиганды терпиридинового ряда: модификация наночастиц золота, получение координационных соединений с CuI, катализ реакций окисления. 2010, № 9, с. 1335-1344 0,725