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Конкурсы Программа PostDoc в Ведущих Лабораториях и Инфраструктурах, конкурс - Короткий Визит

Passport project

Project name

D

Project managers

Dr., PhD in chemistry, Doctor of sciences, Lomonosov Moscow State University, Chemistry Department, Associate professor,  Deputy Dean Alexander Majouga

Project objectives

The target of the project is development and realization of new approach to bi-functional magnetic nano-materials synthesis, pattern determination, structure – magnetic properties, in order to validate their use for biomedical applications. The plan is to create a panel of magnetic nanoparticles- based medications to combat cancer of various etiologies by modified advanced antitumor drugs. 

Equipment

Cell block: 

laminar flow unit, 

СО2 incubator, 

microbioreactor, 

fluorescence microscope, 

optical microscope.

Chemical laboratory:

Remotely controlled rotary evaporator, 

rotary evaporator coolant, 

magnetic mixer with heating, 

magnetic mixer without heating, 

remotely controlled vacuum system, 

digital block heater, 

hotplate, 

stirring shaft, 

lab centrifuge, 

analytical balances, 

analytical balance 2200 г - 0,01gr, built-in calibration, 

lab spray-freeze drying, 

Dewar flask, 

water production block I type pH-metrinometer, 

UltraSonic Bath, 

autocellcounter, 

flatbed spectrophotometer with cell holder, 

lab chest cooler/freezer, 

digital vacuum pressure gauge, 

hot air gun, digital steam sterilizer, 

electric laboratory dishes dryer, 

drying chamber, 

lamellation/ rotatory vacuum pump with oil seal, 

immersion thermostat, 

trap refrigerator.

Physical and chemical research methods:

electrokinetic potential analyzer, 

size and molecular weight.

Patents

Patent application “Device to study the impact of low-frequency magnetic field on the kinetics of bio-chemical processes in biological systems containing magnetic nano particles”. Y.Golovin, A.Samodurov, S.Gribanovsky, A.Shuklinov, N.L.Klyachko, A.G. Majouga, A.Kabanov 30.12.2014 № 2014153860, Russia

Patent application  “TELOMERASE INHIBITING COMPOSITION” A.G.Majouga, N.L.Klyachko, M.E.Zvereva, O.A. Dontsova, T.Bronich, A.Kabanov  30.12.2014 №2014153863 Russia

Partnership and cooperation

International cooperation:

1.     Massachusetts Institute of Technology, Boston, USA Professor Dan Andersen. Joint research to obtain tissue-specific ligand for magnetic nano particles modification and their guided transportation to liver and prostate.

2.     University of Nottingham (UK), Professor A.N.Khlobystov. Joint research of advanced magnetic nanoparticles and carbon nanotubes based materials. Such material will be used as instruments of targeted delivery of antitumor drugs.

3.     Pharmaceutical faculty of the University of North Carolina (USA), Professor A.V.Kabanov.  oint research of new magnetic materials. Such structures consist of magnetite nanoparticle, vector fragments and anticancer drug, fixed on the surface of the nanopartcicle.

Home cooperation:

1.     Lomonosov Moscow State University (fine organic synthesis of ligands for modification and stabilization of magnetic nanomaterials) A.Majouga, N.V.Klyachko

2.  Lomonosov Moscow Institute of Fine Chemical Technology (Professor M.A.Green) Obtaining agents for photodynamic therapy and nano hybrid materials based on them.

3.Mendeleev Russian Chemical Technological University (Professor E.V.Yurtov) Developing method of magnetite nanoparticles synthesis.

4. Skolkovo Institute of Science and Technology (Professor V.E.Kotelyansy) Developing low-molecular tissue specific ligands for delivering magnetic nanoparticles to prostate.

5.Pirogov Russian National Research Medical University (Professor V.P.Chekhonin) Use of magnetic nanoparticles as contrast agents for magnetic resonance tomography.

 6. Gertsen Moscow Scientific Research Oncology Institute (Professor R.I.Yakubovskaya) Creation of animal models of prostate, liver cancer, Erlikh sarcoma, in-vivo experiments.

7. Derhzavin Tambov State University (Professor Y.I.Golovin). Developing devices to study the impact of low-frequency magnetic field on biological processes.

 

8. Bioclinicum Scientific Technological Centre, (General Director D.A.Sakharov) Using microbioreactor for simultaneous co-culturing mammals cells.

 Publications


2014Majouga A.G.,  Gerasimov V.M., Beloglazkina E.K.Mixed Valence Copper(I,II) Binuclear Complexes with Unexpected Structure: Synthesis, Biological Properties and Anticancer ActivityJournal of Medicinal chemistry
2014Majouga A.G., Beloglazkina E.K., Machulkin A.E., Chufarova N.V.Design, synthesis and biological evaluation of novel potent MDM2/p53 small molecule inhibitorsBioorganic & Medicinal Chemistry Letters
2014Majouga A.G., Beloglazkina E.K.New type of organic/gold nanohybrid material: preparation, properties and application in catalysisApplied Surface Science
2014Majouga A.G., Beloglazkina E.KMononuclear ruthenium (II) and rhodium (III) complexes with S-[4-(2,2:6’,2’’-terpyridin-4’-yl)phenoxy]butyl ethanethionate and 4’-[4-(1,2-dithiolane-3-yl)butilcarboxy)phenil]-2,2’:6’2’’-terpyridine: Synthesis, electrochemistry, antibacterial activity and catalytical applicationPolyhedron
2014Majouga A.G., Chufarova N.V.Dietary Polyphenols for Prostate Cancer TherapyCurrent Bioactive Compounds
2014Majouga A.G., Beloglazkina E.KEnzyme-Functionalized Gold-Coated Magnetite 
Nanoparticles as Novel Hybrid Nanomaterials: Synthesis, 
Purification and Control of Enzyme Function by 
Low-Frequency Magnetic Field 
Colloids and Surfaces B: Biointerfaces
2015Salihov, SV (Salihov, Sergei V.)[ 1 ] ; Sviridenkova, NV (Sviridenkova, Natalia V.)[ 1 ] ; Savchenko, AG (Savchenko, Alexander G.)[ 1 ] ; Klyachko, NL (Klyachko, Natalya L.)[ 1,2 ] ; Golovin, YI (Golovin, Yury I.)[ 2 ] ; Beloglazkina, EK (Beloglazkina, Elena K.)[ 1,2 ] ; Majouga, AG (Majouga, Alexander G.Recent advances in the synthesis of Fe3O4@AU core/shell nanoparticlesJOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
2015Majouga, AG (Majouga, A. G.)Effects of cadmium chloride on the functional state of human intestinal cellsТом: 29 Выпуск: 5 Стр.: 1006-1011 
2015Pantiushenko, IV (Pantiushenko, I. V.)[ 1 ] ; Rudakovskaya, PG (Rudakovskaya, P. G.) Abakumov, MA (Abakumov, M. A.)[ 5 ] ; Majouga, AG (Majouga, A. G.)[ 2,3 ] ; Grin, MA (Grin, M. A.)Development of Bacteriochlorophyll a-Based Near-Infrared Photosensitizers Conjugated to Gold Nanoparticles for Photodynamic Therapy of CancerBIOCHEMISTRY-MOSCOW
2015Majouga, AG (Majouga, Alexander G.)[ 1,2 ] ; Beloglazkina, EK (Beloglazkina, Elena K.)Oxidative dehydrogenation of 5-(pyridine-2-yl-methyl)-2-thioxo-4-imidazolidinones in complexation reaction with copper(II) chlorideINORGANIC CHEMISTRY COMMUNICATIONS
2015Golovin, Y (Golovin, Y.)[ 1,3 ] ; Klyachko, N (Klyachko, N.)[ 2,3 ] ; Majouga, A (Majouga, A.)Alternative low frequency magnetic field theranostics: recent advances, safety and hazardsNANOBIOTECH 2015
2015Golovin, Yuri I; Klyachko, Natalia L; Majouga, Alexander G; Towards nanomedicines of the future: Remote magneto-mechanical actuation of nanomedicines by alternating magnetic fields.Journal of controlled release : official journal of the Controlled Release Society
2015Rudakovskaya, P (Rudakovskaya, Polina); Metelkina, O (Metelkina, Olga); Beloglazkina, E (Beloglazkina, Elena Savchenko, A (Savchenko, Alexander); Schetinin, I (Schetinin, Igor); Salihov, S (Salihov, Sergey); Abakumov, M (Abakumov, Maxim); Klyachko, N (Klyachko, Nataliya);Golovin, Y (Golovin, Yuriy); Majouga, A (Majouga, Alexander).SYNTHESIS AND CHARACTERIZATION OF PEG-SILANE FUNCTIONALIZED IRON OXIDE (II, III) NANOPARTICLES FOR BIOMEDICAL APPLICATIONNanotechnologies in Russia
2015Наномеханическое управление свойствами биологических мембран с помощью стержнеобразных магнитных наночастиц в супернизкочастотном магнитном полеНаномеханическое управление свойствами биологических мембран с помощью стержнеобразных магнитных наночастиц в супернизкочастотном магнитном полеПисьма в ЖТФ
2015Ю.И. Головин 1−4 , Н.Л. Клячко 2−4 , С.Л.. МажугаМодель контролируемого высвобождения лекарств из функциональных магнитных наночастиц негреющим переменным магнитным полемПисьма в ЖТФ
2015Alexander G. MajougaIn silico approaches to the design of NS5A inhibitorsCurrent Topics in Medicinal Chemistry
2015Alexander G. Majouga A Comprehensive Insight into the Chemical Space and ADME Features of Small Molecule NS5A InhibitorsCurrent Topics in Medicinal Chemistry
2015Roman L. Antipin, Elena K. Beloglazkina,a 
Alexander G. Majougaa,b* 
An Improved Protocol for Synthesis of 3-Substituted 5-Arylidene-2- 
thiohydantoins: Two-step Procedure Alternative to Classical Methods 
Journal of Heterocyclic Chemistry 
2016Majouga, Alexander G.Synthesis, characterisation, cytotoxicity and antibacterial activity of ruthenium(II) and rhodium(III) complexes with sulfur-containing terpyridinesPOLYHEDRON
2016Majouga, A. G.Model of controlled drug release from functionalized magnetic nanoparticles by a nonheating alternating-current magnetic fieldTECHNICAL PHYSICS LETTERS
2016Majouga, Alexander G.A Comprehensive Insight into the Chemical Space and ADME Features of Small Molecule NS5A InhibitorsCURRENT TOPICS IN MEDICINAL CHEMISTRY
2016Мajouga, Alexander G.Computational insight into the chemical space of plant growth regulatorsPHYTOCHEMISTRY
2016Majouga, A. G., Garanina A.S.Magnetocontrollability of Fe7C3@C superparamagnetic nanoparticles in living cellsJOURNAL OF NANOBIOTECHNOLOGY
2016 Stop-Frame Filming and Discovery of New Reactions atthe Single-Molecule Level by Transmission Electron MicroscopyACS Nano
2016Aleksey Nikitin, Majouga Alexander, Maksim Abakumov.Formation of colloidal nanocrystal clusters of iron oxide under thermal decompositionLangmuir
2016Мажуга А.Г.Современные стратегии лекарственной терапии заболеваний печени сприменением средств нацеленной доставкиУспехи химии
2016Мajouga Alexander G., Ivan S. Grebennikov, Olga N. MetelkinaNanoscale Engineering of Hybrid Magnetite-Carbon Nanofibre Materials for Magnetic Resonance Imaging Contrast AgentsJournal of Materials Chemistry
2016Мajouga, Alexander G.In Silico Approaches to the Design of NS5A InhibitorsCURRENT TOPICS IN MEDICINAL CHEMISTRY
2017Мажуга А.Г., Абакумов М.А.Fe3O4-Au dumbbell nanoparticles as all-in-one theranostics agents with superior MRI relaxivity and magneto-mechanical actionAdvanced Materials
2017Ефремова М.В., Абакумов М.А., Науменко В.А., Преловская А.О., Мажуга А.Г.All-in-one platform for theranostics based on Fe3O4-Au hybrid nanoparticles: from physical insights to real time in vivo trackingScientific Reports
2017Абакумов М.А.Multiparametric optimization of DNA-immunization furthers a strong Th2-polarized immune response against the wild-type and drug-resistant variants of HIV-1 reverse transcriptaseScientific Reports
2017Абакумов М.А., Мажуга А.Г.Synthesis and investigation of photophysical and biological properties of novel S-containing bacteriopurpurinimidesJournal of Medicinal Chemistry
2017Семкина А.С., Абакумов М.А., Мажуга А.Г.Multimodal doxorubicin loaded magnetic nanoparticles for VEGF targeted theranostics of breast cancerNanomedicine: Nanotechnology, Biology and Medicine
2017Семкина А.С., Науменко В.А., Абакумов М.А., Мажуга А.Г.Bacteriochlorin loaded magnetic nanoparticles for personalized MRI guided photodynamic cancer therapyNanomedicine
2017Мажуга А.Г., Ефремова М.А.In situ Observation of Chymotrypsin Catalytic Activity Change Actuated by Non-Heating Low-Frequency Magnetic Field/ACS Nano

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