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Laboratory of Physical methods, acousto-optic and laser apparatus for cancer diagnostics and therapy

Associate fellow, Russian Academy of Sciences, Dr. Sci. in Physics and Mathematics Efim A.Khazanov

Project target

This project is a unique combination of advanced developments in the field of acousto optics and laser physics for biomedical purpose – oncology. The projects concentrates on the use of new disperse methods to control acousto-optic devices to monitor femtosecond laser radiation and hyperspectral image analysis.

Project objectives

1.           Development and creation of hyperspectral acousto-optic system to study fluorescence spectrum of microbiological objects.

2.           Research of auto fluorescence of human tumor tissues and development of new methods of differential diagnostics of cancer.

3.           Theoretical and experimental research of factors which limit spectral and dimensional resolution of acousto-optic systems.

4.           Development of principals of dispersed acousto-optic control of laser and incoherent optic radiation to form random spectral transmission functions of acousto-optic filters and correction of complex spectra of femtosecond radiation.

5.            Development and testing laser driver for photosensitive cathodes with acousto-optic laser impulse control system for FEL accelerator in positron emission tomography

6.           Development of technology of growing crystals with low dislocation density of high optic quality and low dissipation to create new generation of acousto-optic devices for biomedical purposes.

Uniqueness project

The projects is targeted to solve socially important problem of treating cancer. The significance of the project lies in creation of key new generation components for devices of cancer andron therapy, based on compact laser sources and highly-energized particle accelerators. The project also deals with new diagnostics criteria for differential diagnostics and determining human malignant tumours. 


·       Femtosecond laser Femtosource Synergy (Femtolasers, Austria).

·       Femtosecond autocorrelator  Femtometer (Femtolasers, Austria).

·       Regenerative magnifier RAP-2000 (Avesta project, Russia).

·       MIIPSBox-640 ultrashort light laser pulse diagnostic system (Biophotonic Solitions, USA).

·       Arbitrary waveform generator N8241A (Agilent, USA).

·        Arbitrary waveform generator 33622А (Keysight, USA).

·       Spectrum optical analyzer 86142В (Agilent, USA).

·       Argon laser 488 nм (Melles Griot, USA).

·       Solid laser 532 nм (Laser Quantum, UK).

·       High frequency amplifiers (Amplifier Research, USA).

·       Radio signal spectrum analyzer FSH3 (Rhode&Schwarz, Germany).

·     Radio signal power meter NRT-Z14 (Rhode&Schwarz, Germany).

·       X-ray diffractometer (Rigaku, Japan).

·       Automated system for cutting crystals and plates APD2 (Logitech, UK).

·       Polishing finishing optic instrument OLP 200/C (AKM, Germany).

·       Interferometer OptoTL-60 (Optcal technical lab, Russia).

·       Ultrasound washing line (Selecta, Spain).

·       Vacuum evaporation device (Torr, USA)

·       Thermocompression bonding device(Kulicke&Soffa, USA).

·       Vector network analyzer E5061A (Agilent, USA).

·       Medical biological microscope Ti-E (Nikon, Japan).

·       Hyperspectral system HSi-300 (Gooch & Housego, USA).

·       Cooled CCD chamber Alta U32 (Apogee Instruments, USA).

·       Precision optic tables (Thorlabs, USA).

·       Optic station (Thorlabs, USA).


Acousto-optic commutator of laser telecommunication channels from N mainstream dataset to M mainstream dataset/ RF patent for utility model RU 149705 U1 dated 10.12.2014 (priority from 25.09.2014)

Events research team

·       VII International Exhibition «Integrated Safety and Security -2014», Moscow , All-Russia Exhibition Center, 20-23 May 2014

·       X International Specialized Exhibition Photonics World of Lasers and Optics 2015 Moscow, Expocentre, 16-19 March 2015

·       VIII International Exhibition «Integrated Safety and Security -2014», Moscow, All-Russia Exhibition Center, 19-22 May 2015 

Partnership and cooperation

·       Gdansk University, Poland. Cooperation agreement 2015-2017. Research in the field of molecular acoustics and photodynamic therapy of oncology diseases.

·       Université de Valenciennes, France. Cooperation agreement 2016-2018. Research in the field of nonisotropic medium optics and periodical structures based on them.

·        University of Bordeaux France. Research in the field of nonisotropic medium optics and periodical structures based on them..

·        AdlOptica GmbH Germany. Development of optical system for hyperspectral image analysis in near- and middle IR range

·       Institute of Applied Physics RAS, Nizhny Nivgorod. Laser radiation parameters control  in super powerful systems of ultra short impulses for forming diagnostical and therapy streams of charged particles.

·      Endocrinology research centre, RF Ministry of Healthcare, г. Москва. Immunological and molecular genetic research of thyroid body tumor

·       Lomonosov Moscow State University, Moscow. Acoustics of highly anisotropic medium, optic systems for hyperspectral image analysis.  


2014P.V. Belousov, A.V. Bogolyubova, Y.S. Kim, A.Y. Abrosimov, et al.Serum immunoproteomics combined with pathological reassessment of surgical specimens identifies TCP-1ζ autoantibody as a potential biomarker in thyroid neoplasia Journal of Clinical Endocrinology and Metabolism
2014K.B. Yushkov, V.Ya. Molchanov, P.V. Belousov, A.Yu. AbrosimovContrast enhancement in microscopy of human thyroid tumors by means of acousto-optic adaptive spatial filteringJournal of Biomedical Optics
2014S.Yu. Mironov, V.N. Ginzburg, Е.I. Gacheva, D.E. Silin, A.A. Kochetkov, Yu.A. Mamaev, A.A. Shaykin, E.A. Khazanov and G.A. MourouUse of polyethylene terephthalate for temporal recompression of intense femtosecond laser pulsesLaser Physics Letters
2014N.F. NaumenkoAdvanced numerical technique for analysis of surface and bulk acoustic waves in resonators using periodic metal gratingsJournal of Applied Physics
2014N.F. NaumenkoOptimal orientations of LiTaO3 for application in plate mode resonatorsJournal of Applied Physics
2014S.N. Mantsevich, V.I. Balakshy, V.Ya. Molchanov, K.B. YushkovInfluence of acoustic anisotropy in paratellurite on quasicollinear acousto-optic interactionUltrasonics
2014A.L. ShuvalovBulk longitudinal wave reflection/transmission in periodic piezoelectric structures with metallized interfacesUltrasonics
2015N.F. Naumenko 
V.Ya. Molchanov 
S.I. Chizhikov 
K.B. Yushkov 
Anisotropic diffraction of bulk acoustic wave beams in lithium niobateUltrasonics
2015N.F. NaumenkoDispersion of lamb waves under a periodic metal grating in aluminum nitride platesIEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control
2015A.A. Kutsenko, A.L. Shuvalov, O. Poncelet and A.N. DarinskiiTunable effective constants of the one-dimensional piezoelectric phononic crystal with internal connected electrodesJournal of the Acoustical Society of America
2015K.B. Yushkov, V.Ya. MolchanovAcousto-optic filters with arbitrary spectral transmissionOptics Communications
2015S. Tretiakov, A. Kolesnikov, I. Kaplunov, R. Grechishkin, K. Yushkov, E. ShmelevaThermal imaging and conoscopic studies of working acoustooptical devices on the base of paratelluriteInternational Journal of Thermophysics
2015I.A. Kaplunov, 
R.M. Grechishkin, 
A.I. Kolesnikov 
Magneto-optical imaging and analysis of magnetic field micro-distributions with the aid of biased indicator filmsJournal of Crystal Growth
2015Н.В. Диденко, 
А.В. Конященко, 
П.В. Кострюков, 
Л.Л. Лосев, В.С. Пазюк, 
С.Ю. Теняков, В.Я. Молчанов, 
С.И. Чижиков, К.Б. Юшков 
40-fs hydrogen Raman laserКвантовая электроника
2015В.И. Балакший, А.С. Волошин, В.Я. МолчановАнизотропная дифракция света в кристаллах с большим сносом акустической энергииОптика и спектроскопия
2015С.П. Аникин, В.Ф. Есипов, В.Я. Молчанов, А.М. Татарников, К.Б. ЮшковАкустооптический спектрометр изображений для астрофизических измеренийОптика и Спектроскопия
2015K.B. Yushkov, S.P. Anikin, S.I. Chizhikov, V.F. Esipov, A.I. Kolesnikov, O.Yu. Makarov, V.Ya. Molchanov, S.A. Potanin and A.M. TatarnikovRecent Advances in Acousto-optic Instrumentation for AstronomyActa Physica Polonica A
2015S. Tretiakov, R. Grechishkin, A. Kolesnikov, I. Kaplunov, K. Yushkov, V. Molchanov and B.B.J. LindeCharacterization of temperature field distribution in large-size paratellurite crystals applied in acousto-optic devicesActa Physica Polonica A
2015A.I. Kolesnikov, S.A. Tretiakov, R.M. Grechishkin, K.A. Morozova, K.B. Yushkov, V.Ya. Molchanov and B.B.J. LindeA study of optical uniformity of lithium niobate and paratellurite crystals by the method of conoscopyActa Physica Polonica A
2015A.V. Ovchinnikov, O.V. Chefonov, V.Ya. Molchanov, K.B. Yushkov, C. Vicario, C. HauriGeneration of frequency-tunable pulsed terahertz radiation from a Cr:forsterite laser with an acousto-optic control of the temporal pulse profileQuantum Electronics
2015V.Ya. Molchanov 
K.B. Yushkov
A compact acousto-opic hyperspectral polarimeter fo near-infrared imagingOptics Express
2015А.Ю. Абросимов, 
Н.Ю. Двинских, А.В. Сидорин 
Cells of Benign and Borderline Thyroid Tumor Express Malignancy Markers.Бюллетень эксперименталь¬ной биологии и медицины
2016К.Б. Юшков,
В.Я. Молчанов 
70 GHz arbitrary modulation of chirped laser pulses by means of acousto-opticsOptics Letters
2016А.Н. ДаринскийFinite element analysis of the Rayleigh wave scattering in isotropic bi-material wedge structuresUltrasonics
2016Е.А. Хазанов, 
К.Б. Юшков,
А.И. Чижиков, 
В.Я. Молчанов 
Rectangular laser pulse train profiling and temporal noise filtering by acousto-optical methodOptics Express
2016А.Н. ДаринскийNumerical simulation of surface acoustic wave transmission in composite Ultrasonics
2016К.Б. Юшков,
В.Я. Молчанов, 
Ж.-К. Кастелик 
Double acousto-optic deflector system for increased scanning range of laser beamsUltrasonics
2016Р.М. ГречишкинMagneto-optical imaging and analysis of magnetic field micro-distributions with the aid of biased indicator filmsJournal of Applied Physics
2016Абросимов А.Ю.Мутации промотора теломеразной обратной транскриптазы (TERT) в опухолях эндокринной системы человека: биологическое и прогностическое значениеАрхив патологии
2017V.Ya. Molchanov, 
K.B. Yushkov 
Acoustic field structure simulation in quasi-collinear acousto-optic cells with ultrasound beam reflectionUltrasonics
2017V.Ya. Molchanov, 
K.B. Yushkov 
Hyperspectral imaging acousto-optic system with spatial filtering for optical phase visualizationJournal of Biomedical Optics
2017K.B. Yushkov,
V.Ya. Molchanov 
Acousto-optic replication of ultrashort laser pulsesPhys. Rev. A
2017K.B. Yushkov,
S.P. Anikin, 
S.N. Mantsevich, 
V.Ya. Molchanov 
Compact acousto-optic imaging spectropolarimeter for mineralogical investigations in the near infraredOptics Express
2017A.N. DarinskiiFE analysis of surface acoustic wave transmission in composite piezoelectric wedge structuresUltrasonics
2017A.N. DarinskiiSurface acoustic wave electric field effect on acoustic streaming: Numerical analysisJ. Appl. Phys.
2018A.N. DarinskiiPhonon interference control of atomic-scale metamirrors, meta-absorbers, and heat transfer through crystal interfacesPhys. Rev. B.
2018K.B. Yushkov 
A.I. Chizhikov, 
O.Yu. Makarov, 
V.Ya. Molchanov 
Laser-ultrasonic temperature mapping of an acousto-optic dispersive delay lineNDT & E International
2018S.I. ChizhikovOn the mechanism of pulsed laser ablation of phthalocyanine nanoparticles in an aqueous mediumLaser Physics Letters
2018N.F. NaumenkoMultilayered structures using thin plates of LiTaO3 for acoustic wave resonators with high quality factorUltrasonics
2018V.Ya. Molchanov 
K.B. Yushkov 
Interference of phase-shifted chirped laser pulses for secure free-space optical communicationsApplied Optics

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